%0 Journal Article
%T Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy
%A Guanjun Deng
%A Jiali Zhang
%A Lihua Zhou
%A Lintao Cai
%A Ping Gong
%A Sanpeng Li
%A Wenjun Li
%A Xiaoqing Meng
%A Zhihong Sun
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26607
%X Hypoxia is a common characteristic of solid tumors. This important feature is associated with resistance to radio-chemotherapy, which results in poor prognosis and probability of tumor recurrence. Taking advantage of background-free NIR II fluorescence imaging and deeper-penetrating photoacoustic (PA) imaging, we developed a hypoxia-triggered and nitroreductase (NTR) enzyme-responsive single molecule probe for high-contrast NIR II/PA tumor imaging and hypoxia-activated photothermal therapy (PTT), which will overcome cellular resistance during hypoxia.
%K hypoxia-triggered
%K single molecule probe
%K NIR II fluorescence imaging
%K PA imaging
%K activatable photothermal therapy.
%U http://www.thno.org/v08p6025.htm