%0 Journal Article
%T The Role of Nitric Oxide during Sonoreperfusion of Microvascular Obstruction
%A Adam C. Straub
%A Francois T.H. Yu
%A John J. Pacella
%A Xucai Chen
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.19422
%X Rationale: Microembolization during PCI for acute myocardial infarction can cause microvascular obstruction (MVO). MVO severely limits the success of reperfusion therapies, is associated with additional myonecrosis, and is linked to worse prognosis, including death. We have shown, both in in vitro and in vivo models, that ultrasound (US) and microbubble (MB) therapy (termed ¡°sonoreperfusion¡± or ¡°SRP¡±) is a theranostic approach that relieves MVO and restores perfusion, but the underlying mechanisms remain to be established.
%K Microvascular obstruction
%K ultrasound
%K microbubbles
%K sonothrombolysis
%K nitric oxide
%U http://www.thno.org/v07p3527.htm