%0 Journal Article
%T Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer
%A Benjamin Gibert
%A David Goldschneider
%A Frederic Padilla
%A Jacqueline Ngo
%A Jean-Guy Delcros
%A Jennifer Wischhusen
%A Juergen K. Willmann
%A Katheryne E. Wilson
%A Patrick Mehlen
%A Rodolfo Molina-Pe£ża
%A Shan Jiang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.27221
%X In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference therapy requires the assessment of netrin-1 expression prior to treatment. In this study, we studied netrin-1 as a target for USMI and its potential as a companion diagnostic in breast cancer models.
%K ultrasound molecular imaging
%K netrin-1
%K companion diagnostic
%K breast cancer
%K targeted microbubbles
%U http://www.thno.org/v08p5126.htm