%0 Journal Article
%T Increased recruitment of endogenous stem cells and chondrogenic differentiation by a composite scaffold containing bone marrow homing peptide for cartilage regeneration
%A Antonios G. Mikos
%A Changfeng Lu
%A Chenhao Wang
%A Heyong Yin
%A Jiaju Lu
%A Jiang Peng
%A Lingyun Zhao
%A Quanyi Guo
%A Shibi Lu
%A Shuhui Yang
%A Xianqi Dong
%A Xiaodan Sun
%A Xiumei Wang
%A Xuezhen Shen
%A Xun Sun
%A Yifan Liu
%A Yingqi Huang
%A Yu Wang
%A Zijin Yang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26981
%X Even small cartilage defects could finally degenerate to osteoarthritis if left untreated, owing to the poor self-healing ability of articular cartilage. Stem cell transplantation has been well implemented as a common approach in cartilage tissue engineering but has technical complexity and safety concerns. The stem cell homing-based technique emerged as an alternative promising therapy for cartilage repair to overcome traditional limitations. In this study, we constructed a composite hydrogel scaffold by combining an oriented acellular cartilage matrix (ACM) with a bone marrow homing peptide (BMHP)-functionalized self-assembling peptide (SAP). We hypothesized that increased recruitment of endogenous stem cells by the composite scaffold could enhance cartilage regeneration.
%K self-assembling peptide hydrogel
%K acellular cartilage matrix
%K stem cell homing
%K cartilage regeneration
%U http://www.thno.org/v08p5039.htm