%0 Journal Article
%T Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPAR¦Ã
%A Fan Yao
%A Grant M. Hatch
%A Hongwei Du
%A Junnan Li
%A Li Chen
%A Linjing Feng
%A Ming Zhang
%A Shengnan Wei
%A Yang Yu
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22565
%X The mechanism by which adipocyte-derived endocrine factors promote insulin resistance in skeletal muscle are not fully understood. MiR-27a is highly expressed in sera of obese individuals with prediabetes and T2DM, and mainly derived by adipose tissues. Thus, miR-27a secreted into circulation by adipose tissue may regulate insulin resistance in skeletal muscle.
%K miR-27a
%K adipocyte
%K skeletal muscle
%K insulin resistance
%K exosome
%K PPAR¦Ã
%U http://www.thno.org/v08p2171.htm