%0 Journal Article
%T Tumor-targeted Dual-modality Imaging to Improve Intraoperative Visualization of Clear Cell Renal Cell Carcinoma: A First in Man Study
%A Christina A. Hulsbergen-Van de Kaa
%A Constantijn H. Muselaers
%A Egbert Oosterwijk
%A Johan F. Langenhuijsen
%A Mark Rijpkema
%A Marl¨¨ne C. Hekman
%A Otto C. Boerman
%A Peter F. Mulders
%A Wim J. Oyen
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.23335
%X Intraoperative imaging with antibodies labeled with both a radionuclide for initial guidance and a near-infrared dye for adequate tumor delineation may overcome the main limitation of fluorescence imaging: the limited penetration depth of light in biological tissue. In this study, we demonstrate the feasibility and safety of intraoperative dual-modality imaging with the carbonic anhydrase IX (CAIX)-targeting antibody 111In-DOTA-girentuximab-IRDye800CW in clear cell renal cell carcinoma (ccRCC) patients.
%K carbonic anhydrase IX
%K clear cell renal cell carcinoma
%K intraoperative dual-modality imaging
%K fluorescence imaging
%K image-guided surgery
%U http://www.thno.org/v08p2161.htm