%0 Journal Article
%T Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKK£¿/TBK1/NF-¦ÊB signaling
%A Chaping Cheng
%A Chenlu Zhang
%A Helen He Zhu
%A Huifang Zhao
%A Jianming Zhang
%A Jinming Wang
%A Jufang Yao
%A Li Wang
%A Wei-Qiang Gao
%A Xiaoxia Li
%A Xue Wang
%A Yanjing Guo
%A Yaru Sheng
%A Yujiao Sun
%A Yuman He
%A Zhongzhong Ji
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26687
%X Tumor metastasis is the major cause of death for prostate cancer (PCa) patients. However, the treatment options for metastatic PCa are very limited. Epithelial-mesenchymal transition (EMT) has been reported to be an indispensable step for tumor metastasis and is suggested to associate with acquisition of cancer stem cell (CSC) attributes. We propose that small-molecule compounds that can reverse EMT or induce mesenchymal-epithelial transition (MET) of PCa cells may serve as drug candidates for anti-metastasis therapy.
%K Amlexanox
%K prostate cancer
%K metastasis
%K IKK-£¿/TBK1
%K mesenchymal-epithelial transition
%U http://www.thno.org/v08p4633.htm