%0 Journal Article
%T ATP-activated decrosslinking and charge-reversal vectors for siRNA delivery and cancer therapy
%A Chenggen Qian
%A David Oupicky
%A Gang Chen
%A Huipeng Li
%A Minghua Zhang
%A Minjie Sun
%A Qingyan Zhang
%A Zhanwei Zhou
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26889
%X Stimuli-responsive polycations have been developed for improved nucleic acid transfection and enhanced therapeutic efficacy. The most reported mechanisms for controlled release of siRNA are based on polyelectrolyte exchange reactions in the cytoplasm and the degradation of polycations initiated by specific triggers. However, the degradation strategy has not always been sufficient due to unsatisfactory kinetics and binding of cationic fragments to siRNA, which limits the gene silencing effect. In this study, a new strategy that combines degradation and charge reversal is proposed.
%K ATP-responsive
%K charge reversal
%K phenylboronic acid
%K siRNA delivery
%K cancer therapy
%U http://www.thno.org/v08p4604.htm