%0 Journal Article
%T UHRF1 is an Independent Prognostic Factor and a Potential Therapeutic Target of Esophageal Squamous Cell Carcinoma
%A Jianxian Huang
%A Jiecheng Ye
%A Lihui Wang
%A Weiye Liang
%A Xueyun Zhong
%A Yong Zhang
%J Journal of Cancer
%D 2017
%I Ivyspring International Publisher
%R 10.7150/jca.21256
%X Purpose: Ubiquitin-like with plant homeodomain and ring-finger domains 1 (UHRF1) plays an essential role in DNA methylation, and the overexpression of UHRF1 is associated with poor prognosis in various cancers. Esophageal squamous cell carcinoma (ESCC) accounts for approximately 90% of esophageal cancer cases in China, but the five-year survival rate for patients is less than 10% due to limited clinical approaches for early diagnosis and treatment. The present research aimed to investigate the expression of UHRF1 in ESCC and its biological role in ESCC development.
%K DNA methylation
%K esophageal squamous cell carcinoma
%K prognosis
%K UHRF1
%K Wee1
%U http://www.jcancer.org/v08p4027.htm