%0 Journal Article
%T Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery
%A Azita Lotfi
%A Carleena A. Ortega
%A Frederick J. Schoen
%A In-Hyun Lee
%A Jerry Liu
%A Jinjun Shi
%A Kevin Si
%A Mikyung Yu
%A Mirna M. B. Brayner
%A Morteza Mahmoudi
%A Omid C. Farokhzad
%A Peter Libby
%A Phei Er Saw
%A Renata F. C. Leitao
%A Roberto Molinaro
%A Sangyong Jon
%A Suyeon Ahn
%A Xiaoding Xu
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.24365
%X Extra domain B of fibronectin (FN-EDB) is upregulated in the extracellular matrix during tissue remodeling and has been postulated as a potential biomarker for atherosclerosis, yet no systematic test for FN-EDB in plaques has been reported. We hypothesized that FN-EDB expression would intensify in advanced plaques. Furthermore, engineering of FN-EDB-targeted nanoparticles (NPs) could enable imaging/diagnosis and local delivery of payloads to plaques.
%K atherosclerosis
%K aptides
%K extra domain B of fibronectin
%K magnetic resonance imaging
%K nanoparticles
%U http://www.thno.org/v08p6008.htm