%0 Journal Article
%T MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome
%A Andrew J. Bodey
%A Bart Bijnens
%A Catherine Disney
%A Gustavo Egea
%A Hua Geng
%A J¨²lia L¨®pez-Guimet
%A Luc¨ªa Pe£¿a-P¨¦rez
%A Michael J. Sherratt
%A Patricia Garc¨ªa-Canadilla
%A Philip J. Withers
%A Robert S. Bradley
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26598
%X Aortic wall remodelling is a key feature of both ageing and genetic connective tissue diseases, which are associated with vasculopathies such as Marfan syndrome (MFS). Although the aorta is a 3D structure, little attention has been paid to volumetric assessment, primarily due to the limitations of conventional imaging techniques. Phase-contrast microCT is an emerging imaging technique, which is able to resolve the 3D micro-scale structure of large samples without the need for staining or sectioning.
%K Marfan syndrome
%K microCT
%K aorta
%K ageing
%K elastic lamella
%U http://www.thno.org/v08p6038.htm