%0 Journal Article
%T Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis
%A Andrea Gr¨¹tzkau
%A Anne-Laure Mausset-Bonnefont
%A Christian Jorgensen
%A Christine Roubert
%A Clara Ponsolles
%A Florence Apparailly
%A Gabriel Courties
%A Gautier Roussignol
%A Isabelle Duroux-Richard
%A Jessy Presumey
%A Joachim Gr¨¹n
%A Karine Toupet
%A Leonie Taams
%A Maxime Robin
%A Ma£¿lys Cren
%A Meryem Ammari
%A Philippe Georgel
%A Ramzi Nehmar
%A Thomas H£¿upl
%A Virginie Escriou
%A Yves-Marie Pers
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.29313
%X Rationale: Monocytes play critical roles in the pathogenesis of arthritis by contributing to the inflammatory response and bone erosion. Among genes involved in regulating monocyte functions, miR-146a negatively regulates the inflammatory response and osteoclast differentiation of monocytes. It is also the only miRNA reported to differentially regulate the cytokine response of the two classical Ly6Chigh and non-classical Ly6Clow monocyte subsets upon bacterial challenge. Although miR-146a is overexpressed in many tissues of arthritic patients, its specific role in monocyte subsets under arthritic conditions remains to be explored.
%K monocyte subsets
%K miR-146
%K osteoclast
%K bone erosion
%K arthritis
%U http://www.thno.org/v08p5972.htm