%0 Journal Article
%T Dual-Modality ImmunoPET/Fluorescence Imaging of Prostate Cancer with an Anti-PSCA Cys-Minibody
%A Anna M Wu
%A Kirstin A Zettlitz
%A Naoko Kobayashi
%A Richard Tavar¨¦
%A Robert E Reiter
%A Wenting K Tsai
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.27679
%X Inadequate diagnostic methods for prostate cancer lead to over- and undertreatment, and the inability to intraoperatively visualize positive margins may limit the success of surgical resection. Prostate cancer visualization could be improved by combining the complementary modalities of immuno-positron emission tomography (immunoPET) for preoperative disease detection, and fluorescence imaging-guided surgery (FIGS) for real-time intraoperative tumor margin identification. Here, we report on the evaluation of dual-labeled humanized anti-prostate stem cell antigen (PSCA) cys-minibody (A11 cMb) for immunoPET/fluorescence imaging in subcutaneous and orthotopic prostate cancer models.
%K immunoPET
%K fluorescence
%K prostate cancer
%K antibody fragment
%K molecular imaging
%U http://www.thno.org/v08p5903.htm