%0 Journal Article
%T Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells
%A Feifei Li
%A Jin Li
%A Pengcheng Zhang
%A Qiang Li
%A Weiqiang Chen
%A Xiaodong Jin
%A Yan Liu
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22172
%X Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed.
%K tumor
%K radiation therapy
%K metal-based nanoparticles
%K NanoEnhancers
%K radiosensitization
%K synergistic chemo-radiotherapy
%U http://www.thno.org/v08p1824.htm