%0 Journal Article %T RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice %A Chi-Wei Chang %A Chia-Hung Hsieh %A En-Peng Ho %A Fu-Ju Lei %A Min-Wei Huang %A Ren-Shyan Liu %A Woei-Cherng Shyu %A Yu-Jung Lin %J Theranostics %D 2018 %I Ivyspring International Publisher %R 10.7150/thno.25189 %X Rationale: Although molecular investigations of regulator of G-protein signaling 4 (RGS4) alterations in schizophrenia patients yielded partially inconsistent findings, the previous studies suggested that RGS4 is both a positional and functional candidate gene for schizophrenia and is significantly decreased in the prefrontal cortex. However, the exact role of RGS4 in the pathophysiology of schizophrenia is unclear. Moreover, a whole genome transcription profile study showed the possibility of RGS4-regulated expression of SLC7A11(xCT), a component of cysteine/glutamate transporter or system xc-. We hypothesized that system xc- is a therapeutic target of RGS4 deficit-mediated schizophrenia. %K regulator of G-protein signaling 4 %K system xc- %K schizophrenia %K glutamatergic transmission %K N-acetyl cysteine %U http://www.thno.org/v08p4781.htm