%0 Journal Article
%T RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice
%A Chi-Wei Chang
%A Chia-Hung Hsieh
%A En-Peng Ho
%A Fu-Ju Lei
%A Min-Wei Huang
%A Ren-Shyan Liu
%A Woei-Cherng Shyu
%A Yu-Jung Lin
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.25189
%X Rationale: Although molecular investigations of regulator of G-protein signaling 4 (RGS4) alterations in schizophrenia patients yielded partially inconsistent findings, the previous studies suggested that RGS4 is both a positional and functional candidate gene for schizophrenia and is significantly decreased in the prefrontal cortex. However, the exact role of RGS4 in the pathophysiology of schizophrenia is unclear. Moreover, a whole genome transcription profile study showed the possibility of RGS4-regulated expression of SLC7A11(xCT), a component of cysteine/glutamate transporter or system xc-. We hypothesized that system xc- is a therapeutic target of RGS4 deficit-mediated schizophrenia.
%K regulator of G-protein signaling 4
%K system xc-
%K schizophrenia
%K glutamatergic transmission
%K N-acetyl cysteine
%U http://www.thno.org/v08p4781.htm