%0 Journal Article
%T Biodegradable Hollow Mesoporous Silica Nanoparticles for Regulating Tumor Microenvironment and Enhancing Antitumor Efficiency
%A Jiamin Tang
%A Miao Kong
%A Qi Qiao
%A Songwei Tan
%A Tingting Wu
%A Xueqin Gao
%A Yan Qi
%A Zhiping Zhang
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.19987
%X There is accumulating evidence that regulating tumor microenvironment plays a vital role in improving antitumor efficiency. Herein, to remodel tumor immune microenvironment and elicit synergistic antitumor effects, lipid-coated biodegradable hollow mesoporous silica nanoparticle (dHMLB) was constructed with co-encapsulation of all-trans retinoic acid (ATRA), doxorubicin (DOX) and interleukin-2 (IL-2) for chemo-immunotherapy. The nanoparticle-mediated combinational therapy provided a benign regulation on tumor microenvironment through activation of tumor infiltrating T lymphocytes and natural killer cells, promotion of cytokines secretion of IFN-¦Ã and IL-12, and down-regulation of immunosuppressive myeloid-derived suppressor cells, cytokine IL-10 and TGF-¦Â. ATRA/DOX/IL-2 co-loaded dHMLB demonstrated significant tumor growth and metastasis inhibition, and also exhibited favorable biodegradability and safety. This nanoplatform has great potential in developing a feasible strategy to remodel tumor immune microenvironment and achieve enhanced antitumor effect.
%K nanoparticles
%K tumor microenvironment
%K immunosuppression
%K drug delivery
%K cancer treatment.
%U http://www.thno.org/v07p3276.htm