%0 Journal Article
%T Platelet-Targeted Delivery of Peripheral Blood Mononuclear Cells to the Ischemic Heart Restores Cardiac Function after Ischemia-Reperfusion Injury
%A Alex Bobik
%A Bock Lim
%A Christoph E. Hagemeyer
%A Dexing Huang
%A Ephraem Leitner
%A Franco Klingberg
%A Helen Kiriazis
%A Ingo Ahrens
%A Jody J. Haigh
%A Karlheinz Peter
%A Melanie Ziegler
%A Victoria Ching
%A Xiao-Jun Du
%A Xiao-Ming Gao
%A Xiaowei Wang
%A Yu Yao
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.19698
%X One of the major hurdles in intravenous regenerative cell therapy is the low homing efficiency to the area where these cells are needed. To increase cell homing toward areas of myocardial damage, we developed a bispecific tandem single-chain antibody (Tand-scFvSca-1+GPIIb/IIIa) that binds with high affinity to activated platelets via the activated glycoprotein (GP)IIb/IIIa receptor, and to a subset of peripheral blood mononuclear cells (PBMC) which express the stem cell antigen-1 (Sca-1) receptor.
%K cell delivery
%K single-chain antibody
%K targeting
%K myocardial infarction
%K PBMC
%K regenerative cell therapy
%K cell tracking.
%U http://www.thno.org/v07p3192.htm