%0 Journal Article
%T ¦Á-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
%A Bang Yeon Hwang
%A Beom Joon Kim
%A Cheong-Yong Yun
%A Jae Mun Kim
%A Jin Tae Hong
%A Jin Yong Song
%A Ju Yeon Kim
%A Jungno Lee
%A Sang-Bae Han
%A Seon Mi Ko
%A Song-Hee Kim
%A Yong Pyo Choi
%A Youngsoo Kim
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.24385
%X Rationale: cAMP up-regulates microphthalmia-associated transcription factor subtype M (MITF-M) and tyrosinase (Tyro) in the generation of heavily pigmented melanosomes. Here, we communicate a therapeutic mechanism of hyperpigmented disorder by ¦Á-viniferin, an active constituent of Caragana sinica.
%K ¦Á-viniferin
%K Caragana sinica
%K PKA inactivation
%K feedback loop
%K melanogenesis
%U http://www.thno.org/v08p2031.htm