%0 Journal Article
%T UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy
%A Dan Li
%A Fan Li
%A Feng Gao
%A Lianfang Du
%A Lifang Jin
%A Lizhou Lin
%A Peng Qin
%A Qiusheng Shi
%A Wenjie Sun
%A Xiangyang Shi
%A Yu Fan
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22834
%X Conventional chemotherapy of pancreatic cancer (PaCa) suffers the problems of low drug permeability and inherent or acquired drug resistance. Development of new strategies for enhanced therapy still remains a great challenge. Herein, we report a new ultrasound-targeted microbubble destruction (UTMD)-promoted delivery system based on dendrimer-entrapped gold nanoparticles (Au DENPs) for co-delivery of gemcitabine (Gem) and miR-21 inhibitor (miR-21i).
%K ultrasound-targeted microbubble destruction
%K PAMAM dendrimers
%K gold nanoparticles
%K drug delivery
%K gene delivery
%K pancreatic cancer
%U http://www.thno.org/v08p1923.htm