%0 Journal Article
%T Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection
%A Bingran Yu
%A Chen Xu
%A Feiran Qi
%A Fu-jian Xu
%A Jie Du
%A Ke Xu
%A Lixin Jia
%A Ping Li
%A Yanzhenzi Zhang
%A Yulin Li
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22467
%X Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI.
%K Thoracic aortic dissection
%K Early diagnosis
%K Risk prediction
%K Magnetic resonance imaging
%K Fluorescence imaging.
%U http://www.thno.org/v08p0437.htm