%0 Journal Article
%T Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents
%A Andrew G. Cheetham
%A Barbara Holt
%A Honggang Cui
%A Lei Xing
%A Liwen Chen
%A Qin Fan
%A Ran Lin
%A Yanyu Xiao
%A Zhipeng Chen
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.19404
%X We report here on the covalent conversion of the anti-inflammatory agent ketoprofen into self-assembling prodrugs that enable the effective purification of ketoprofen enantiomers, the improved selectivity and potency of ketoprofen, as well as the formation of one-component drug-bearing supramolecular hydrogels. We found that the ketoprofen hydrogelator could exhibit much-enhanced selectivity for cyclooxygenase 2 (COX-2) over COX-1, reduce the concentration of inflammatory cytokines (IL-1 and TNF¦Á), and induce apoptosis in fibroblast-like synoviocytes while maintaining biocompatibility with healthy chondrocytes. In addition, these anti-inflammatory agent-containing hydrogels demonstrated the ability to retain the therapeutic within a joint cavity after intra-articular injection, exhibiting a slow, steady release into the plasma. We believe that upon further optimization these drug-based injectable supramolecular hydrogels could provide the basis for a local treatment strategy for rheumatoid arthritis and similar conditions.
%K supramolecular hydrogel
%K self-assembly
%K drug delivery
%K peptide-drug conjugate
%K rheumatoid arthritis.
%U http://www.thno.org/v07p2003.htm