%0 Journal Article
%T Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles
%A Annette Burkhart
%A Fredrik Melander
%A Kasper Bendix Johnsen
%A Maj Schneider Thomsen
%A Martin Bak
%A Morten Schallburg Nielsen
%A Paul Joseph Kempen
%A Thomas Lars Andresen
%A Torben Moos
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.25228
%X Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy to give a preferential accumulation of drugs or nanomedicines, but several aspects of this targeting strategy remain elusive. Here we report that TfR-targeted gold nanoparticles (AuNPs) can accumulate in brain capillaries and further transport across the BBB to enter the brain parenchyma.
%K Brain drug delivery
%K gold nanoparticle
%K transferrin receptor
%K targeting
%K affinity
%U http://www.thno.org/v08p3416.htm