%0 Journal Article
%T Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy
%A Guo-En Wang
%A Hiroshi Kurihara
%A Hong-Min Yu
%A Long-Fang Tu
%A Rong-Rong He
%A Shu-Hua Ouyang
%A Wei-Lin Yuan
%A Wen-Jun Duan
%A Xi Wang
%A Yan-Ping Wu
%A Yi-Fang Li
%A Youwei Zhang
%A Zhong-Ze Fang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.28778
%X Skin cells are vulnerable to oxidative stress-induced senescence, which may lead to abnormal aging or aging-related disorders. Therefore, strategies that can ameliorate oxidative stress-induced senescence are expected to protect skin from damage, holding the promise of treating skin diseases in the clinic. This study aims to investigate whether caffeine, a well-known purine alkaloid, is able to prevent skin from oxidative stress-induced senescence, and to explore the underlying molecular mechanisms.
%K autophagy
%K caffeine
%K cellular senescence
%K skin aging
%K UV radiation
%U http://www.thno.org/v08p5713.htm