%0 Journal Article
%T Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics
%A Anjali Sharma
%A Kevin Liaw
%A Rangaramanujam M. Kannan
%A Rishi Sharma
%A Sujatha Kannan
%A Zhi Zhang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.29039
%X Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to translate into clinical success due to their nonspecific cellular localization, poor transport properties across multiple biological barriers, and associated side effects. These challenges, coupled with the complex function of the mitochondria, create the need for innovative delivery strategies.
%K Hydroxyl PAMAM dendrimer
%K mitochondria
%K activated microglia
%K sub-cellular targeting
%K oxidative stress
%K N-acetyl cysteine
%U http://www.thno.org/v08p5529.htm