%0 Journal Article
%T In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis
%A Andrew Arthur
%A Aria Ahmed-Cox
%A Arnaud Charil
%A Arvind Parmar
%A David Zahra
%A Eugene Yee
%A Federica Saletta
%A Florida Voli
%A Giancarlo Pascali
%A Gita Rahardjo
%A Giuseppe Cirillo
%A Guo Jun Liu
%A Kathleen Kimpton
%A Luigi Lerra
%A Maria Kavallaris
%A Nigel Lengkeek
%A Orazio Vittorio
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.29840
%X Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, copper homeostasis is considered as an emerging target for anticancer drug design. Monitoring copper levels in vivo is therefore of paramount importance when assessing the efficacy of copper-targeting drugs. Herein, we investigated the activity of the copper-targeting compound Dextran-Catechin by developing a [64Cu]CuCl2 PET imaging protocol to monitor its effect on copper homeostasis in tumors.
%K Copper
%K Anticancer drugs
%K PET
%K Neuroblastoma
%K Molecular imaging
%U http://www.thno.org/v08p5645.htm