%0 Journal Article
%T S6K1 phosphorylation-dependent degradation of Mxi1 by ¦Â-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer
%A Gang Wu
%A Junjie Chen
%A Kai Huang
%A Kaishun Hu
%A Kunyu Yang
%A Li Liu
%A Rui Meng
%A Shaojun Shi
%A Sheng Zhang
%A Shuangbing Xu
%A Tao Zhang
%A Xiaofang Dai
%A Xiaorong Dong
%A Yingchao Zhao
%A Yu Zhang
%A Yumei Huang
%A Zhongyuan Yin
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22552
%X Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly understood.
%K Mxi1
%K S6K1
%K ¦Â-Trcp
%K phosphorylation
%K lung cancer
%U http://www.thno.org/v08p1286.htm