%0 Journal Article
%T Potential Red-Flag Identification of Colorectal Adenomas with Wide-Field Fluorescence Molecular Endoscopy
%A Annelies Jorritsma-Smit
%A Arend Karrenbeld
%A Dominic J. Robinson
%A Elisabeth G.E. de Vries
%A Elmire Hartmans
%A Gooitzen M. van Dam
%A Jan H. Kleibeuker
%A Jolien J.J. Tjalma
%A Mariana e Silva de Oliveira Nery
%A Marjory Koller
%A Matthijs D. Linssen
%A Pilar Beatriz Garcia Allende
%A Sjoerd G. Elias
%A Vasilis Ntziachristos
%A Wouter B. Nagengast
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.22033
%X Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial growth factor A (VEGFA), which is highly upregulated in colorectal adenomas.
%K optical molecular imaging
%K spectroscopy
%K vascular endothelial growth factor a
%K near-infrared fluorescence.
%U http://www.thno.org/v08p1458.htm