%0 Journal Article
%T Tumor-suppressing miR-141 gene complex-loaded tissue-adhesive glue for the locoregional treatment of hepatocellular carcinoma
%A Chung Kil Song
%A Min-Kyoung Kim
%A Rengarajan Baskaran
%A Sijeong Bae
%A Su-Geun Yang
%A Young-Ah Moon
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.24056
%X microRNAs (miRNAs) regulate gene expression post-transcriptionally and have been extensively tested as therapeutic molecules against several human diseases. In vivo delivery of miRNAs needs to satisfy the following conditions: safety, efficiency, and long-term therapeutic effectiveness. To satisfy these conditions, we developed a tissue-adhesive nucleotide-polymer complex (NPX-glue) for in vivo delivery of miRNAs to treat hepatocellular carcinoma (HCC).
%K miR-141
%K nucleotide complex
%K tissue adhesive glue
%K hepatic cancer
%K gene delivery
%U http://www.thno.org/v08p3891.htm