%0 Journal Article
%T Profiling the circulating miRnome reveals a temporal regulation of the bone injury response
%A Andreia M. Silva
%A Carla Cunha
%A Cl¨˘udia Ribeiro-Machado
%A Cristina Ivan
%A Daniel Vasconcelos
%A George A. Calin
%A Joana Oliveira
%A Jos¨¦ H. Teixeira
%A Maria I. Almeida
%A M¨˘rio A. Barbosa
%A Nuno Neves
%A Susana G. Santos
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.24444
%X Bone injury healing is an orchestrated process that starts with an inflammatory phase followed by repair and remodelling of the bone defect. The initial inflammation is characterized by local changes in immune cell populations and molecular mediators, including microRNAs (miRNAs). However, the systemic response to bone injury remains largely uncharacterized. Thus, this study aimed to profile the changes in the plasma miRnome after bone injury and determine its biological implications.
%K inflammation
%K bone tissue repair
%K plasma
%K microRNA
%K biomarker
%U http://www.thno.org/v08p3902.htm