%0 Journal Article
%T miR-618 Inhibits Prostate Cancer Migration and Invasion by Targeting FOXP2
%A Shan-Chao Zhao
%A Xian-Lu Song
%A Xiang-Hui Lei
%A Yao Tang
%A Zi-Qing Wu
%J Journal of Cancer
%D 2017
%I Ivyspring International Publisher
%R 10.7150/jca.17407
%X miRNAs play critical role in the development and progression of prostate cancer. Here we studied the role of miR-618 in prostate cancer migration and invasion. miR-618 was downregulated in metastatic androgen-independent prostate cancer (AIPC), patients with low miR-618 had poor outcome. Overexpression of miR-618 inhibited migration and invasion and induced mesenchymal to epithelial transition (MET). Conversely, knockdown of miR-618 promoted migration and invasion and induced epithelial to mesenchymal transition (EMT). FOXP2 was the direct target of miR-618, and promoted TGF-¦Â expression, inhibition of TGF-¦Â reversed the effect of miR-618 knockdown. We further analyzed the correlation between miR-618 expression and FOXP2 in human prostate cancer tissues, and found there was a negative correlation between miR-618 expression and FOXP2 levels. In conclusion, we found miR-618 inhibited prostate cancer migration and invasion by targeting FOXP2 and inhibiting TGF-¦Â.
%K prostate cancer
%K miR-618
%K FOXP2
%K migration
%K TGF-¦Â.
%U http://www.jcancer.org/v08p2501.htm