%0 Journal Article
%T Targeting Metabolic Remodeling in Triple Negative Breast Cancer in a Murine Model
%A Alejandro Zentella-Dehesa
%A Carlo Cort¨¦s-Gonz¨¢lez
%A Carlos P¨¦rez-Plasencia
%A C¨¦sar L¨®pez-Camarillo
%A Eduardo L¨®pez-Urrutia
%A Miguel ¨¢. ¨¢vila-Rodr¨ªguez
%A Nadia J Jacobo-Herrera
%A Octavio Villanueva-S¨¢nchez
%A Ver¨®nica Garc¨ªa-Castillo
%J Journal of Cancer
%D 2017
%I Ivyspring International Publisher
%R 10.7150/jca.16387
%X Background: Chemotherapy is the backbone of systemic treatment for triple negative breast cancer (TNBC), which is one of the most relevant breast cancers molecular types due to the ability of tumor cells to develop drug resistance, highlighting the urgent need to design newer and safer drug combinations for treatment. In this context, to overcome tumor cell drug resistance, we employed a novel combinatorial treatment including Doxorubicin, Metformin, and Sodium Oxamate (DoxMetOx). Such pharmacological combination targets indispensable hallmarks of cancer-related to aerobic glycolysis and DNA synthesis.
%K Triple Negative Breast Cancer (TNBC)
%K metformin
%K oxamate
%K doxorubicin
%K mTOR
%K aerobic glycolysis
%K xenograft
%K micro PET.
%U http://www.jcancer.org/v08p0178.htm