%0 Journal Article
%T Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men
%A Dominic W. Chung
%A Jennie Le
%A Jos¨¦ A. L¨®pez
%A Junmei Chen
%A Minhua Ling
%A Susan M. Graham
%A W. Conrad Liles
%J International Journal of Medical Sciences
%D 2019
%R 10.7150/ijms.28110
%X Background: Endothelial activation caused by HIV-1 infection leads to release of von Willebrand factor (VWF), which enters the circulation or attaches to vessel walls and self-assembles into strings and fibers, enabling platelet adhesion; this adhesive activity is regulated by the VWF-cleaving protease ADAMTS13. Our objective was to assess VWF adhesive activity and ADAMTS13 protease activity in HIV-1 infection.
%K HIV-1
%K von Willebrand factor
%K ADAMTS13 protein
%K apolipoprotein A1
%K thrombosis
%U http://www.medsci.org/v16p0276.htm