%0 Journal Article
%T A Pilot Study of Aberrant CpG Island Hypermethylation of SPRED1 in Acute Myeloloid Leukemia
%A Jingwen Sun
%A Jinjing Zhang
%A Rui Zhang
%A Yan Li
%A Yue Wang
%J International Journal of Medical Sciences
%D 2019
%R 10.7150/ijms.27757
%X Background: Epigenetic silencing of tumor suppressor genes plays important role in acute myeloid leukemia (AML). Recently, SPRED1, a negative regulator of the RAS MAPK pathway, is identified as a tumour suppressor downregulated in AML. However, little is known regarding its underlying dysregulation in AML. In this study, we investigated methylation status of SPRED1 promoters and their association with mRNA levels in AML.
%K SPRED1
%K DNA methylation
%K AML
%K Tumor suppressor gene
%U http://www.medsci.org/v16p0324.htm