%0 Journal Article
%T SENP1 Interacts with HIF1¦Á to Regulate Glycolysis of Prostatic Carcinoma Cells
%A Chunyang Wang
%A Qiyin Chen
%A Shaobin Ni
%A Weiyang Tao
%J International Journal of Biological Sciences
%D 2019
%R 10.7150/ijbs.27256
%X Background: Hypoxic microenvironment inside the tumor forces tumor cells to up-regulate the glycolytic pathway to maintain a sufficient energy supply for tumor growth. Activation of HIF1¦Á under hypoxia condition is able to regulate the expression of glycolysis-related genes, and results in the proliferation and metastasis of cancer cells. However, the mechanism underlying HIF1¦Á activation and glycolysis induction by hypoxia remains unclear. The present study is aimed to test if SENP1 regulates the glycolysis of prostate cancer cells (CaP) by improving stability of HIF1¦Á protein.
%K SENP1
%K HIF1¦Á
%K glycolysis
%K prostatic carcinoma
%K tumorgenesis.
%U http://www.ijbs.com/v15p0395.htm