%0 Journal Article
%T Complete Genome Sequence of Actinomadura Parvosata Subsp. Kistnae, A Rich Source of Novel Natural Product (Bio-)Chemistry
%A Kalina Kusserow
%A Tobias A. M. Gulder
%J Journal of Genomics
%D 2017
%R 10.7150/jgen.19673
%X The soil dwelling actinomycete strain Actinomadura parvosata subsp. kistnae is the producer of the antiviral antibiotics kistamicin A and B. Genome sequencing and bioinformatic analysis revealed the presence of the kistamycin biosynthetic gene cluster responsible for the formation of these non-ribosomal peptides as well as an impressive number of yet uncharacterized biosynthetic pathways. This includes polyketide, ribosomal and non-ribosomal peptide and a large number of terpenoid biosynthetic loci encoding yet unknown natural products. The genomic data of this strain is thus a treasure trove for genome mining for novel functional metabolites and new biocatalysts.
%K Actinomadura parvosata subsp. kistnae
%K whole-genome sequencing
%K Kistamicin.
%U http://www.jgenomics.com/v05p0075.htm