%0 Journal Article
%T Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
%A Berolla Sahdo
%A Bo S£¿derquist
%A Emeli M£¿nsson
%A Eva S£¿rndahl
%A £¿sa Nilsdotter-Augustinsson
%J Journal of Bone and Joint Infection
%D 2018
%R 10.7150/jbji.21567
%X Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted.
%K Staphylococcus epidermidis
%K prosthetic joint infections
%K host-pathogen interaction
%K caspase-1
%K neutrophils
%U http://www.jbji.net/v03p0010.htm