%0 Journal Article
%T In vitro study of new combinations for local antibiotic therapy with calcium sulphate - Near constant release of ceftriaxone offers new treatment options
%A Christoph Meier
%A Emanuel Gautier
%A Karolin R£¿nn
%A Laurent A Decosterd
%A Marc Bohner
%A Michel Schl£¿ppi
%A Peter Wahl
%A Sandrine Festa
%J Journal of Bone and Joint Infection
%D 2018
%R 10.7150/jbji.26218
%X Introduction: Local application of antibiotics provides high concentrations at the site of interest, with minimal systemic toxicity. Carrier materials might help manage dead space. Calcium sulphate (CaSO4) has a dissolution time that only slightly exceeds the usually recommended duration of systemic antibiotic treatments. This in vitro study evaluates compatibility, release kinetics and antibacterial activity of new combinations of antibiotics with CaSO4 as carrier material.
%K Calcium sulphate
%K CaSO4
%K in vitro elution
%K antibiotics
%K ceftriaxone
%U http://www.jbji.net/v03p0212.htm