%0 Journal Article
%T Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI
%A Adam E. Hansen
%A Andreas Kj£¿r
%A Axel Haase
%A Benedikt Feuerecker
%A Christian Hundshammer
%A Christoph A. M¨¹ller
%A Franz Schilling
%A Jan-Bernd H£¿vener
%A Jorge Cabello
%A Katja Steiger
%A Markus Schwaiger
%A Mathias Schillmaier
%A Miriam Braeuer
%A Steffen J. Glaser
%A Stephan D¨¹wel
%A Stephan G. Nekolla
%A Wilko Weichert
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.25162
%X Modern oncology aims at patient-specific therapy approaches, which triggered the development of biomedical imaging techniques to synergistically address tumor biology at the cellular and molecular level. PET/MR is a new hybrid modality that allows acquisition of high-resolution anatomic images and quantification of functional and metabolic information at the same time. Key steps of the Warburg effect-one of the hallmarks of tumors-can be measured non-invasively with this emerging technique. The aim of this study was to quantify and compare simultaneously imaged augmented glucose uptake and LDH activity in a subcutaneous breast cancer model in rats (MAT-B-III) and to study the effect of varying tumor cellularity on image-derived metabolic information.
%K PET/MR
%K [18F]FDG-PET
%K hyperpolarized 13C-MRSI
%K DNP
%K diffusion-weighted imaging
%K multimodal imaging
%K NMR
%K spectroscopy
%U http://www.thno.org/v08p4765.htm