%0 Journal Article
%T Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy
%A Chul Soon Yong
%A Han-Gon Choi
%A Jae-Hoon Chang
%A Jong Oh Kim
%A Kishwor Poudel
%A Liyuan Jiang
%A Raj Kumar Thapa
%A Sae Kwang Ku
%A Wenquan Ou
%A Zar Chi Soe
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26758
%X The efficacy of combined near-infrared (NIR) and immune therapies for inhibiting tumor growth and recurrence has gained increasing research attention. Regulatory T cells in the tumor microenvironment constitute a major obstacle in achieving robust CD8+ T cell antitumor immunotherapy. In the present study, we designed a photoimmunotherapy-based strategy involving a combination of photothermal and photodynamic therapies, followed by Treg cell suppression, for eliciting an immune response with IR-780- and imatinib-loaded layer-by-layer hybrid nanoparticles.
%K imatinib
%K immunotherapy
%K IR-780
%K layer by layer
%K photodynamic therapy
%K photothermal therapy
%K Treg cell
%U http://www.thno.org/v08p4574.htm