%0 Journal Article
%T Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors
%A Aki Sugano
%A Hideo Nakayama
%A Kazuki Fukuzawa
%A Mariko Haruna
%A Masahiro Tohkin
%A Noriko Takahata
%A Ryosuke Yoshioka
%A Shinji Kobuchi
%A Taro Hayakawa
%A Toshiki Hayase
%A Toshiyuki Sakaeda
%A Yukako Ito
%A Yutaka Takaoka
%J International Journal of Medical Sciences
%D 2018
%R 10.7150/ijms.22224
%X Objectives: In Japan, sodium-glucose co-transporter type 2 (SGLT2) inhibitors have been reported to be associated with serious skin and subcutaneous tissue disorders. A post-marketing surveillance (PMS) study suggested that the association was specific for ipragliflozin and, to a lesser extent for dapagliflozin. These studies were performed to confirm the association of 6 SGLT2 inhibitors with serious skin disorders in a clinical setting, to elucidate the role of melanin in serious skin disorders and to understand the underlying mechanisms.
%K Sodium-glucose co-transporter type 2 (SGLT2)
%K skin and subcutaneous tissue disorders
%K ipragliflozin
%K dapagliflozin
%U http://www.medsci.org/v15p0937.htm