%0 Journal Article
%T G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1
%A Jian Ding
%A Jie Zhang
%A Pengxing He
%A Yafang Wang
%A Yanyan Shen
%A Yi Chen
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.23824
%X Rationale: G9a is genetically deregulated in various tumor types and is important for cell proliferation; however, the mechanism underlying G9a-induced carcinogenesis, especially in colorectal cancer (CRC), is unclear. Here, we investigated if G9a exerts oncogenic effects in CRC by increasing polo-like kinase 1 (Plk1) expression. Thus, we further characterized the detailed molecular mechanisms.
%K G9a
%K polo-like kinase 1 (Plk1)
%K p53
%K colorectal cancer
%K proliferation
%U http://www.thno.org/v08p2884.htm