%0 Journal Article
%T Platelet-camouflaged nanococktail: Simultaneous inhibition of drug-resistant tumor growth and metastasis via a cancer cells and tumor vasculature dual-targeting strategy
%A Chaojian Zhu
%A Dongqi Wu
%A Haijing Qu
%A Jian Zheng
%A Lijia Jing
%A Xiangsheng Shi
%A Xing Jin
%A Xiufeng Yan
%A Yang Wang
%A Yongbo Yang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.23654
%X Multidrug resistance (MDR) poses a great challenge to cancer therapy. It is difficult to inhibit the growth of MDR cancer due to its chemoresistance. Furthermore, MDR cancers are more likely to metastasize, causing a high mortality among cancer patients. In this study, a nanomedicine RGD-NPVs@MNPs/DOX was developed by encapsulating melanin nanoparticles (MNPs) and doxorubicin (DOX) inside RGD peptide (c(RGDyC))-modified nanoscale platelet vesicles (RGD-NPVs) to efficiently inhibit the growth and metastasis of drug-resistant tumors via a cancer cells and tumor vasculature dual-targeting strategy.
%K platelet
%K melanin nanoparticles
%K drug-resistant cancer
%K metastasis inhibition
%K chemo-photothermal therapy
%U http://www.thno.org/v08p2683.htm