%0 Journal Article
%T Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking
%A Chao Chen
%A Fei Luo
%A Hui Xu
%A Jianping Liu
%A Junchao Xue
%A Liang Zhou
%A Min Ling
%A Qian Bian
%A Qian Sun
%A Qizhan Liu
%A Xiangyu Dai
%A Yi Liu
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.27876
%X Rationale: Aberrant bronchial epithelium-fibroblast communication is essential for the airway remodeling that contributes to chronic obstructive pulmonary disease (COPD). Exosomes have emerged as novel mediators of intercellular communication, but their role in cigarette smoke (CS)-induced COPD is unknown. Here, we investigated the role of exosomal miR-21 in the dysfunctional epithelium-fibroblast cross-talk caused by CS.
%K cigarette smoking
%K COPD
%K airway remodeling
%K exosome
%K microRNA
%U http://www.thno.org/v08p5419.htm