%0 Journal Article
%T Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery
%A Bohan Ma
%A Chun Yin
%A Hao Guo
%A Jin Yan
%A Kaishan Tao
%A Min Liu
%A Peng Hou
%A Simeng Wang
%A Wangxiao He
%A Yi Guo
%A Yi Zhou
%A Yijie Li
%A Zhenyuan Bian
%A Zhijie Lei
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.27165
%X Peptides are a rapidly growing class of therapeutics with many advantages over conventional small molecule drugs. Dextrorotary (D)-peptides, with increased enzymatic stability and prolonged plasma half-life in comparison with natural L-peptides, are considered to have great potential as recognition molecules and therapeutic agents. However, the in vivo efficacy of current therapeutic D-peptides is hindered by their inefficient cellular uptake in diseased tissues.
%K gold nanoparticle
%K ultra-small nanoparticle
%K dextrorotary peptide
%K p53
%K biosafety
%U http://www.thno.org/v08p5320.htm