%0 Journal Article
%T Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer
%A Cho Low
%A Dong Kong
%A Fuming Qiu
%A Jian Huang
%A Jun Wu
%A Jun Ye
%A Pu Cheng
%A Qi Huang
%A Shenghang Jin
%A Wenlu Li
%A Wenteng Chen
%A Xinchi Yi
%A Yikun Guo
%A Yongpin Yu
%A YueHua Han
%A Zhigang Chen
%A Zhou Jiang
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.24284
%X Cancer stem-like cells (CSCs) have been proposed as a key driving force of tumor growth and relapse in colorectal cancer (CRC), and therefore, they are promising targets for cancer therapy. Epidemiological evidence has suggested that the daily use of aspirin reduces overall mortality of CRC and the risk of distant metastasis. We investigated the effect and mechanism of aspirin on CSCs in CRC.
%K Aspirin
%K FasL
%K apoptosis
%K cancer stem-like cells
%K colorectal cancer
%U http://www.thno.org/v08p4447.htm