%0 Journal Article
%T Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival
%A Chen Zhao
%A Huiping Sun
%A Jian-Qing Mi
%A Jiang Zhu
%A Jie Xu
%A Junmei Zhao
%A Junmin Li
%A Pier Paolo Pandolfi
%A Qiusheng Chen
%A Saijuan Chen
%A Wu Zhang
%A Xiangqin Weng
%A Xiaojing Yan
%A Yongmei Zhu
%A Zhu Chen
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26900
%X Acute myeloid leukemia (AML) with an NPM1 mutation (NPMc+) has a distinct gene expression signature and displays molecular abnormalities similar to mixed lineage leukemia (MLL), including aberrant expression of the PBX3 and HOXA gene cluster. However, it is unclear if the aberrant expression of PBX3 and HOXA is essential for the survival of NPM1-mutated leukemic cells.
%K NPM1 mutation
%K H3K79 hypermethylation
%K PBX3
%K HOXA9
%K DOT1L inhibitor
%U http://www.thno.org/v08p4359.htm