%0 Journal Article
%T Mycophenolate Mofetil induces c-Jun-N-terminal kinase expression in 22Rv1 cells: an impact on androgen receptor signaling
%A Ondrej Zenata
%A Radim Vrzal
%A Zdenek Dvorak
%J Journal of Cancer
%D 2018
%I Ivyspring International Publisher
%R 10.7150/jca.23648
%X Mycophenolate Mofetil (MYC) is a transplant drug used to prevent rejection in heart and kidneys transplant patients. Inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in de novo synthesis of guanosine nucleotides, was considered as a primary target for MYC. Recently, we described that MYC was activates aryl hydrocarbon receptor and it antagonizes glucocorticoid receptor. Here we describe an androgen receptor (AR) as another off-target for MYC.
%K 22Rv1
%K LNCaP
%K JNK
%K proliferation
%K Mycophenolate
%U http://www.jcancer.org/v09p1915.htm