%0 Journal Article
%T Genomic and epigenetic signatures associated with survival rate in oral squamous cell carcinoma patients
%A Camila Oliveira
%A Francisco Caramelo
%A Francisco Marques
%A Ilda Patr¨Ēcia Ribeiro
%A Isabel Marques Carreira
%A Joana Barbosa Melo
%A Leonor Barroso
%A Lu¨Ēsa Esteves
%J Journal of Cancer
%D 2018
%I Ivyspring International Publisher
%R 10.7150/jca.23239
%X Purpose: Although oral squamous cell carcinoma (OSCC) presents great mortality and morbidity worldwide, the mechanisms behind its clinical behavior remain unclear. Biomarkers are needed to forecast patients' survival and, among those patients undergoing curative therapy, which are more likely to develop tumor recurrence/metastasis. Demonstrating clinical relevance of these biomarkers could be crucial both for surveillance and in helping to establish adjuvant therapy strategies. We aimed to identify genomic and epigenetic biomarkers of OSCC prognosis as well as to explore a noninvasive strategy to perform its detection.
%K Copy number alterations
%K methylation
%K biomarkers
%K OSCC survival
%K recurrence
%K TCGA data
%U http://www.jcancer.org/v09p1885.htm