%0 Journal Article
%T 环状RNA ciRS-7在三阴性乳腺癌中的表达及其对细胞侵袭和迁移的影响
%A 丁平安
%A 刘思桦
%A 刘飞
%A 孟令娇
%A 巨英超
%A 常胜
%A 梅香
%A 潘烁
%A 谷丽娜
%A 韩若琦
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.0855
%X 摘要 目的 探讨环状RNA ciRS-7在三阴性乳腺癌（TNBC）中的表达及其对细胞侵袭和迁移的影响。方法 通过qRT-PCR法检测乳腺癌组织和细胞中ciRS-7的表达水平，分析其与乳腺癌患者临床病理指标之间的关系。用划痕实验和Transwell实验检测沉默ciRS-7后MDA-MB-231和BT-549细胞的迁移和侵袭能力的变化。利用动物实验在体内进行验证。结果 TNBC组织中ciRS-7的相对表达量为（6.52±0.38），显著高于Luminal型（1.56±0.17）（P<0.001）和HER2过表达型乳腺癌组织（2.27±0.66）（P<0.001）以及癌旁正常组织（0.83±0.09）（P<0.001）。ciRS-7表达与分子分型、肿瘤浸润和淋巴结转移明显相关（均P<0.05）；而与患者年龄、肿瘤直径和病理分级无关（均P>0.05）。沉默ciRS-7后，MDA-MB-231和BT-549细胞的迁移和侵袭明显减弱（均P<0.05）。ciRS-7敲低组肺转移瘤数明显减少（P<0.05）。结论 ciRS-7在TNBC中高表达，并可能增强TNBC细胞的侵袭和迁移
%K ciRS-7
%K 三阴性乳腺癌
%K 迁移
%K 侵袭
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%U http://www.zlfzyj.com/CN/abstract/abstract9354.shtml