%0 Journal Article
%T 食管癌放射抵抗相关基因的筛选
%A 代宁涛
%A 冯连杰
%A 刘维鹏
%A 周福有
%A 朱青山
%A 李军扩
%A 马庭炜
%A 魏涛
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1007
%X 摘要 目的 筛选与食管癌放射抵抗相关的基因，为指导临床个体化治疗打下基础。方法 采用基 因芯片技术检测放疗疗效差异最大的两组患者之间差异明显的CNV片段，筛选出这些CNV片段中的代表性基因。进一步从筛选出的高度相关的代表性基因中，利用qPCR进行验证。结果 基因芯片筛查的结果得到显著差异的CNV片段共5个，分别位于3、4、8、11、17号染色体，其中拷贝数缺失的（CN Loss）3个，增加的（CN Gain）1个，杂合性缺失的（LOH）1个。代表性基因分别为ROBO1、NSD2、CSMD3、CADM1、NF1。qPCR验证的放射抵抗相关基因为NSD2和CADM1，主要涉及DNA损伤修复通路和细胞黏附。结论 基因芯片筛选食管癌放射抵抗相关分子标记具有可行性。NSD2和CADM1可能是与食管癌放射抵抗的相关位点
%K 食管癌
%K 放射敏感
%K 放射抵抗
%K 基因芯片
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%U http://www.zlfzyj.com/CN/abstract/abstract9353.shtml